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Public health guidance (CDC Yellow Book 2026) likewise prioritizes staged ascent and acetazolamide/dexamethasone, underscoring the current evidence gap for antioxidants as standard prophylaxis ( In summary, the present results indicate that antioxidants may confer a modest protective effect against AMS and that this effect is physiologically coherent given the contribution of oxidative stress to endothelial dysfunction, vascular permeability, and inflammatory signaling in hypoxia